In 1838, Doctor Holmes accepted his first professorial position, and became professor of anatomy and physiology at Dartmouth. Two years later, he married, and took up the practice of medicine in Boston. In 1847, he returned to his old love, accepting the Parkman professorship of anatomy and physiology, in the Medical School at Harvard. While engaged in teaching, he prepared for publication several important books and reports relating to his profession, and his papers in the various medical journals attracted great attention by their freshness, clearness, and originality. But it is not as a medical man that Doctor Holmes may be discussed in this paper. We have to deal altogether with his literary career,—a career, which for its brilliancy has not been surpassed on this side of the Atlantic. As a poet he differs much from his contemporaries, but the standard he has reached is as high as that which has been attained by Lowell and Longfellow. In lofty verse he is strong and unconventional, writing always with a firm grasp on his subject, and emphasizing his perfect knowledge of melody and metre.